Entree Capital has unveiled a $300 million fund to invest in early-stage crypto and Web3 infrastructure, a move that highlights the growing institutional appetite for blockchain systems that interact seamlessly with modern technology stacks.
The fund will target investments from pre-seed through Series A, supporting founders who are building the foundational layers for mainstream adoption of Web3, the company said in an email Thursday. Targets include artificial intelligence (AI) agents capable of autonomously managing assets within crypto policy frameworks, as well as decentralized physical infrastructure networks (DePIN) and blockchain protocols that use symbolic incentives to coordinate, finance and operate real-world infrastructure.
Entree says its long history in fintech and crypto — including early bets on Stripe, Rapyd, Mesh and Web3 builders like Gen Labs and Breez — positions it to support founders at the intersection of regulated finance and decentralized networks.
Institutional investors are paying close attention to AI agents and DePIN because they function as crypto-native counterparts to two of today’s fastest-growing technology pillars: artificial intelligence and cloud computing.
AI agents promise autonomous asset management governed by crypto policy frameworks, while DePIN networks extend the cloud model by coordinating and financing physical infrastructure. Together, they provide a path to secure, automated and highly scalable digital and real-world services, aligning with institutions’ broader push toward next-generation infrastructure.
