NFL Week 12 2025 Schedule: Rams, Bucs, Bills and Cowboys all in action

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Week 12 of the 2025 NFL season will feature marquee matchups and the first start of a high-profile rookie quarterback.

Los Angeles Rams quarterback Matthew Stafford will face Tampa Bay Buccaneers quarterback Baker Mayfield on Sunday night. The matchup will feature an MVP favorite in Stafford going up against a quarterback who is poised to be in contention for the award in Mayfield. The NFC heavyweight battle could possibly be a matchup that fans will tune into next January.

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Indianapolis Colts quarterback Daniel Jones throws a pass during the first half of an NFL football game against the Atlanta Falcons, Sunday, Nov. 9, 2025, in Berlin, Germany. (AP Photo/Martin Meissner)

One question fans continue to ask is, “Are the Indianapolis Colts real?” There will be no better way to prove that they are than by taking on the crème de la crème of the AFC, the Kansas City Chiefs. Jonathan Taylor has also been mentioned as an MVP candidate as he averages 113 yards per game.

Elsewhere, the Philadelphia Eagles take on the Dallas Cowboys in an extremely important clash for both teams. The Eagles won this year, but questions arose about their struggling offense. Meanwhile, Dak Prescott is playing at an MVP level and will have a big test to see how real Dallas is in terms of playoff contenders.

Shedeur Sanders will make his first NFL start as quarterback for the Cleveland Browns. He will face Las Vegas Raiders star Maxx Crosby, who will face him throughout the match.

Philadelphia Eagles quarterback Jalen Hurts (1) talks with teammates during the first half of an NFL football game against the Detroit Lions, Sunday, Nov. 16, 2025, in Philadelphia. (AP Photo/Matt Rourke)

Read below to see what the rest of the NFL schedule has to offer.

Thursday November 20

Sunday November 23

  • Pittsburgh Steelers @ Chicago Bears (1 p.m. ET)
  • New England Patriots @ Cincinnati Bengals (1 p.m. ET)
  • New York Giants @ Detroit Lions (1 p.m. ET)
  • Minnesota Vikings @ Green Bay Packers (1 p.m. ET)
  • Seattle Seahawks @ Tennessee Titans (1 p.m. ET)
  • Indianapolis Colts @ Kansas City Chiefs (1 p.m. ET)

Los Angeles Rams quarterback Matthew Stafford passes during the first half of an NFL football game against the Seattle Seahawks, Sunday, Nov. 16, 2025, in Inglewood, California. (AP Photo/Gregory Bull)

Tampa Bay Buccaneers running back Sean Tucker (44) celebrates with quarterback Baker Mayfield (6) after scoring a touchdown against the Buffalo Bills during the second half of an NFL football game, Sunday, Nov. 16, 2025, in Orchard Park, New York. (AP Photo/Jeffrey T. Barnes)

  • New York Jets @ Baltimore Ravens (1 p.m. ET)
  • Cleveland Browns @ Las Vegas Raiders (4:05 p.m. ET)
  • Jacksonville Jaguars @ Arizona Cardinals (4:05 p.m. ET)
  • Philadelphia Eagles @ Dallas Cowboys (4:25 p.m. ET)
  • Atlanta Falcons @ New Orleans Saints (4:25 p.m. ET)
  • Tampa Bay Buccaneers @ Los Angeles Rams (8:20 p.m. ET)

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Monday November 24

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