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The Arizona Cardinals will continue to play Jacoby Brissett at center – at least for the next four weeks.
Kyler Murray, the team’s franchise quarterback, was placed on injured reserve with a midfoot sprain that he has been battling since Week 5.
Head coach Jonathan Gannon, who watched Brissett lead his Arizona team to its first win since Week 2 of “Monday Night Football” against the Dallas Cowboys, said it was a “collective decision” to put Murray on IR. He added that the injury is not season-ending and that he hopes Murray can make a full recovery this year.
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Arizona Cardinals quarterback Kyler Murray (1) warms up before the game against the Dallas Cowboys at AT&T Stadium. (Jérôme Miron/Imagn Images)
“Really,” he said via ESPN. “We’ve got a lot of ball to play, and one day at a time. And where he’s at right now is he’s got to pour into his health bucket and get ready to be healthy.”
While it’s never good for a franchise quarterback to land on IR, the Cardinals can’t complain after seeing what Brissett did against the Cowboys on Monday night. Dallas’ porous defense was exploited by the veteran journeyman, who threw for 261 yards and two touchdowns with a passer rating of 115.1 in the 27-17 victory.
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The Cardinals are now 3-5 this year, and things could be a lot different if one of their one-score games during the five-game losing streak they just ended ended. Unfortunately, that’s the nature of the NFL, but the Cardinals know they have the right man at the helm to get the job done until Murray returns.

Jacoby Brissett of the Arizona Cardinals throws against the Dallas Cowboys during the first quarter of the game at AT&T Stadium on November 3, 2025 in Arlington, Texas. (Sam Hodde/Getty Images)
Looking at the schedule, the Cardinals could get Murray back in Week 14 when they face their NFC West opponent, the Los Angeles Rams. That obviously wasn’t what Gannon and the rest of the team wanted to see from Murray’s injury, although he acknowledged the fair assessment that the former No. 1 overall pick’s running ability could prolong the situation due to the way he plays the game.
“Obviously, for him, it prevents him from being fully healthy to go play, and him, as a person and a player that he is, yes,” Gannon said. “And you could look at other things, like this injury for other people, but he played through some things at other positions, if they have them, they can’t play those because of what they’re asked to do.”
Arizona faces some tough opponents over the next four games, starting with a road trip to Seattle to face the NFC West-leading Seahawks on Sunday. The Cardinals then return home for back-to-back games against the San Francisco 49ers and Jacksonville Jaguars before hitting the road for a matchup with the Tampa Bay Buccaneers before the Rams game on Dec. 7, when Murray could return.

Arizona Cardinals No. 1 Kyler Murray watches from the sidelines before an NFL football game against the Los Angeles Rams at State Farm Stadium on November 26, 2023 in Glendale, Arizona. (Ryan Kang/Getty Images)
It’s a tough task for Brissett to take over and lead the Cardinals now given their 3-5 record. But that’s the nature of being a backup quarterback: When your number is called, you have to deliver.
Brissett did that Monday night, and it will be up to him to continue providing that offensive spark for the next month.




